Resolution of two overlapping neutralizing B cell epitopes within a solvent exposed, immunodominant α-helix in ricin toxin's enzymatic subunit
Identifieur interne : 002410 ( Main/Exploration ); précédent : 002409; suivant : 002411Resolution of two overlapping neutralizing B cell epitopes within a solvent exposed, immunodominant α-helix in ricin toxin's enzymatic subunit
Auteurs : David J. Vance [États-Unis] ; Nicholas J. Mantis [États-Unis]Source :
- Toxicon : (Oxford) [ 0041-0101 ] ; 2012.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Residues Y91-T116 of ricin toxin's enzymatic subunit (RTA) constitute an immunodominant loop-helix-loop motif that is the target of two potent toxin neutralizing monoclonal antibodies (mAbs), PB10 and R70. To define the exact epitope(s) recognized by these mAbs, we affinity enriched from a phage-displayed peptide library 12 mers that bound one or both of these mAbs. We report that PB10 recognizes a distinct but overlapping epitope with R70, in which residues Q98, E102, T105, and H106 are central to mAb recognition.
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 000062
- to stream PascalFrancis, to step Curation: 000032
- to stream PascalFrancis, to step Checkpoint: 000062
- to stream Main, to step Merge: 002435
- to stream Main, to step Curation: 002410
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Resolution of two overlapping neutralizing B cell epitopes within a solvent exposed, immunodominant α-helix in ricin toxin's enzymatic subunit</title>
<author><name sortKey="Vance, David J" sort="Vance, David J" uniqKey="Vance D" first="David J." last="Vance">David J. Vance</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Division of Infectious Disease, Wadsworth Center, New York State Department of Health</s1>
<s2>Albany, NY 12208</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mantis, Nicholas J" sort="Mantis, Nicholas J" uniqKey="Mantis N" first="Nicholas J." last="Mantis">Nicholas J. Mantis</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Division of Infectious Disease, Wadsworth Center, New York State Department of Health</s1>
<s2>Albany, NY 12208</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Biomedical Sciences, University at Albany School of Public Health</s1>
<s2>Albany, MY 12201</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Albany, MY 12201</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">12-0344074</idno>
<date when="2012">2012</date>
<idno type="stanalyst">PASCAL 12-0344074 INIST</idno>
<idno type="RBID">Pascal:12-0344074</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000062</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000032</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000062</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000062</idno>
<idno type="wicri:doubleKey">0041-0101:2012:Vance D:resolution:of:two</idno>
<idno type="wicri:Area/Main/Merge">002435</idno>
<idno type="wicri:Area/Main/Curation">002410</idno>
<idno type="wicri:Area/Main/Exploration">002410</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Resolution of two overlapping neutralizing B cell epitopes within a solvent exposed, immunodominant α-helix in ricin toxin's enzymatic subunit</title>
<author><name sortKey="Vance, David J" sort="Vance, David J" uniqKey="Vance D" first="David J." last="Vance">David J. Vance</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Division of Infectious Disease, Wadsworth Center, New York State Department of Health</s1>
<s2>Albany, NY 12208</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mantis, Nicholas J" sort="Mantis, Nicholas J" uniqKey="Mantis N" first="Nicholas J." last="Mantis">Nicholas J. Mantis</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Division of Infectious Disease, Wadsworth Center, New York State Department of Health</s1>
<s2>Albany, NY 12208</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Biomedical Sciences, University at Albany School of Public Health</s1>
<s2>Albany, MY 12201</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Albany, MY 12201</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Toxicon : (Oxford)</title>
<title level="j" type="abbreviated">Toxicon : (Oxford)</title>
<idno type="ISSN">0041-0101</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Toxicon : (Oxford)</title>
<title level="j" type="abbreviated">Toxicon : (Oxford)</title>
<idno type="ISSN">0041-0101</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antigenic determinant</term>
<term>B-Lymphocyte</term>
<term>Helix</term>
<term>Neutralization</term>
<term>Organic solvent</term>
<term>Phage</term>
<term>Ricin</term>
<term>Subunit</term>
<term>Toxin</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Ricine</term>
<term>Neutralisation</term>
<term>Lymphocyte B</term>
<term>Déterminant antigénique</term>
<term>Solvant organique</term>
<term>Helix</term>
<term>Toxine</term>
<term>Sousunité</term>
<term>Bactériophage</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Residues Y<sub>91</sub>
-T<sub>116</sub>
of ricin toxin's enzymatic subunit (RTA) constitute an immunodominant loop-helix-loop motif that is the target of two potent toxin neutralizing monoclonal antibodies (mAbs), PB10 and R70. To define the exact epitope(s) recognized by these mAbs, we affinity enriched from a phage-displayed peptide library 12 mers that bound one or both of these mAbs. We report that PB10 recognizes a distinct but overlapping epitope with R70, in which residues Q<sub>98</sub>
, E<sub>102</sub>
, T<sub>105</sub>
, and H<sub>106</sub>
are central to mAb recognition.</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>État de New York</li>
</region>
</list>
<tree><country name="États-Unis"><region name="État de New York"><name sortKey="Vance, David J" sort="Vance, David J" uniqKey="Vance D" first="David J." last="Vance">David J. Vance</name>
</region>
<name sortKey="Mantis, Nicholas J" sort="Mantis, Nicholas J" uniqKey="Mantis N" first="Nicholas J." last="Mantis">Nicholas J. Mantis</name>
<name sortKey="Mantis, Nicholas J" sort="Mantis, Nicholas J" uniqKey="Mantis N" first="Nicholas J." last="Mantis">Nicholas J. Mantis</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002410 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002410 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= MersV1 |flux= Main |étape= Exploration |type= RBID |clé= Pascal:12-0344074 |texte= Resolution of two overlapping neutralizing B cell epitopes within a solvent exposed, immunodominant α-helix in ricin toxin's enzymatic subunit }}
This area was generated with Dilib version V0.6.33. |